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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10277/212

Autori: Vannini, Nicola
Tutor interno: NOONAN, DOUGLAS
Titolo: Molecular mechanisms of novel angiopreventive compounds.
Abstract: In this thesis I have been studied 2 agents that have shown promising results as cancer chemopreventive. These 2 compounds are: -N-acetyl-cysteine (NAC) -Triterpenoid CDDO-Me (synthetic derived of olanoleic acid) NAC has been widely studied and has already been reported is chemopreventive activity due to its anti-oxidant activity. Here for the first time it has been reported its ability to reduce the expression of an endothelial membrane protein (E-selectin). E-selectin is expressed on endothelial cells and can be used by metastatic cells as ‘docking site’ during metastatic spreading. This proprety of NAC could be a suitable tool for preventive approach of metastatization. CDDO-Me is actually in phase I Clinical trial. It has already been reported its antitumoral proprety. Here we show for the first time its potent antiangiogenic and angiopreventive activity through its interaction with inflammatory and endothelial cells.
Data: 2008
Lingua: en
Corso di dottorato: Medicina Sperimentale e Oncologia
Università di conseguimento titolo: Università degli Studi dell'Insubria
Citazione: Vannini, N.Molecular mechanisms of novel angiopreventive compounds. (Doctoral Thesis, Università degli Studi dell'Insubria, 2008).

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