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Please use this identifier to cite or link to this item: http://hdl.handle.net/10277/249

Authors: Sogno, Ilaria
Internal Tutor: NOONAN, DOUGLAS
Title: Evaluation of the antiangiogenic and angiopreventive activity of nature-based compounds.
Abstract: Several studies demonstrated that angiogenesis is a limiting process for tumour growth and progression. Consequently it is at the same time a potential target for both preventive and therapeutic interventions. Angiogenesis is a multi-step phenomenon that involves different cell types; in particular endothelial cells, tumour cells and immune cells, which orchestrate an intricate network of stimuli aiming to render tumour microenvironment suitable for malignant progression. Here we have demonstrated the anti-angiogenic activity of three compounds derived from naturalling occurring sources: hyperforin (from Saint John’s Wort), methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me) and 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im), both synthetic compounds based on oleanolic acids found in citrus fruits. These compounds could be suitable chemoprevention approaches, and the CDDO derivatives are under study for chemotherapeutic application.
Issue Date: 2009
Doctoral course: Biologia Cellulare e Molecolare
Academic cycle: 22
Publisher: Università degli Studi dell'Insubria
Citation: Sogno, I.Evaluation of the antiangiogenic and angiopreventive activity of nature-based compounds. (Doctoral Thesis, Università degli Studi dell'Insubria, 2009).

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