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Please use this identifier to cite or link to this item: http://hdl.handle.net/10277/302

Authors: Salvaggio, Fabio Salvatore
Internal Tutor: CALLEGARI, CAMILLA
Title: Effetti cardiovascolari dei farmaci antipsicotici di seconda generazione (SGA).
Abstract: Introduction: The QTc prolongation by antipsychotic drugs is of major concern, especially in light of the data indicating an increased risk of sudden death in psychiatric patients taking these drugs. Sudden death in psychiatric patients could be partially attributed to drug-induced torsades de pointes and for this reason careful evaluation of QTc prolonging properties of antipsychotic drugs is needed. Objectives: This study aims to evaluate QTc prolungation effects of second generation antipsychotic drugs Methods: Subjects treated with atypical antipsychotic drugs since October 2008 were enrolled in the study. Patients have been evaluated in two steps with ECG before taking drugs (T0) and after 2 months of therapy. Patients drug-naive or after a pharmachological switch were enrolled. Results: 49 patients (27 men; 22 women) accepted to join the research. 63 % of subjects were drug-naïve, 37 % had been treated before with typical or atypical antipsychotic drugs. Prescribed drugs were Risperidone, Paliperidone, Aripiprazolo, Olanzapine, Ziprasidone and Quetiapine. No significant difference occurred between T0 and T1 in QTc lenght in the whole examined group. Ziprasidone and Olanzapine produced a non-significant drug-induced prolongation of QTc.
Keywords: ecg, qtc, antipsychotic drugs
Subject MIUR : MED/25 PSCHIATRIA
MED/09 MEDICINA INTERNA
Issue Date: 2011
Language: it
Doctoral course: Farmacologia Clinica e Sperimentale
Academic cycle: 23
Publisher: Università degli Studi dell'Insubria
Citation: Salvaggio, F.S.Effetti cardiovascolari dei farmaci antipsicotici di seconda generazione (SGA). (Doctoral Thesis, Università degli Studi dell'Insubria, 2011).

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