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Please use this identifier to cite or link to this item: http://hdl.handle.net/10277/860

Authors: Vanoli, Alessandro
Internal Tutor: SESSA, FAUSTO
FURLAN, DANIELA
Title: Clinico-pathologic, histophenotypic, molecular and prognostic characterization of small bowel carcinomas associated with celiac disease or Chron’s disease.
Abstract: Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Celiac disease and Crohn’s disease are predisposing conditions for small bowel carcinoma development. In this study, small bowel carcinomas associated with celiac disease (n=26), small bowel carcinomas associated with Crohn’s disease (n=25) and sporadic small bowel carcinomas (n=25) were systematically compared. We found that in patients undergoing surgery for small bowel carcinomas the underlying immune-mediated disorder represents a stage-independent prognostic factor. Despite their common origin in a chronically inflamed mucosa, celiac disease-associated and Crohn’s disease-associated small bowel carcinomas differ substantially in tumor cell phenotype, tumor-infiltrating lymphocyte density, microsatellite instability status, Wnt pathway activation, as well as mucosal precursor lesions. Moreover, Epstein-Barr virus-positive carcinomas may occur in the ileum of Crohn’s disease patients and are characterised by increased tumor-infiltrating lymphocytes, either with lymphoepithelioma-like or with a more conventional glandular histology.
Keywords: Small intestine, cancer, adenocarcinoma, celiac disease, Chron disease
Subject MIUR : MED/08 ANATOMIA PATOLOGICA
Issue Date: 2018
Language: eng
Doctoral course: Medicina sperimentale e traslazionale
Academic cycle: 30
Publisher: Università degli Studi dell'Insubria
Citation: Vanoli, A.Clinico-pathologic, histophenotypic, molecular and prognostic characterization of small bowel carcinomas associated with celiac disease or Chron’s disease. (Doctoral Thesis, Università degli Studi dell'Insubria, 2018).

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