Università degli Studi dell'Insubria Insubria Space
 

InsubriaSPACE - Thesis PhD Repository >
Insubria Thesis Repository >
01 - Tesi di dottorato >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10277/920

Authors: Pellegrini, Francesco Paolo
Internal Tutor: ACCOLLA, ROBERTO
Title: Effect of blueberry supplementation in overweight and obese pregnant women
Abstract: Childhood obesity is a serious problem growing worldwide that needs to be early considered and treated. Maternal overweight and obesity lead to foetal complications and to an increased risk of child obesity. Blueberry bio-active compounds have antioxidant properties and improve insulin sensitivity in obese individuals. We proposed a daily integration of a freeze-dried blueberry extract in the last trimester of a population of overweight and obese pregnant women. Mother cytokine milieu, birth weight and at age one, were compared with a matched control group. Results: birth weight was significantly lower in those whose mothers assumed the blueberry extract (male: 3636 gr ± 56,7 in control group and 3302 gr ± 60,9 in the blueberry, P=.001; female: 3446 gr ± 53 in control group and 3094 gr ± 65,5 in the blueberry, P <.0001) and this result remained comparable at age one (male control group: 9597 gr ± 134,4; blueberry: 8656 gr ± 271,9; P=.0021; female control group: 8812 ± 167,5; blueberry: 8083 ± 266,3; P=.0211); pro-inflammatory cytokines (TNF-α and leptin) were significantly reduced in the blueberry group (control 29,89 pg/mL ± 0,283 vs blueberry 8,124 ng/mL ± 0,1085 and 17,28 ± 0,4742 vs 6,977 ± 0,1187, respectively); anti-inflammatory cytokines (TGF-β and IL-4) were significantly increased in the blueberry group (control 4,196 pg/ml ± 0,9752 vs blueberry 14,87 pg/ml ± 0,8844 and 14,87 pg/ml ± 0,8844 vs 55,22 ± 1,47, respectively), CRP levels were significantly lower in the blueberry group (control 5,917 mg/L ± 0,698 vs blueberry 3,741 mg/L ± 0,6279). Conclusion: a daily dietary supplementation with bioactive from whole blueberries in overweight and/or obese pregnant women is an effective intervention to reduce the risk of foetal macrosomia and early childhood obesity.
Keywords: Blueberry, pregnancy, obesity
Subject MIUR : MED/04 PATOLOGIA GENERALE
Issue Date: 2019
Language: ita
Doctoral course: Medicina sperimentale e traslazionale
Academic cycle: 31
Publisher: Università degli Studi dell'Insubria
Citation: Pellegrini, F.P.Effect of blueberry supplementation in overweight and obese pregnant women (Doctoral Thesis, Università degli Studi dell'Insubria, 2019).

Files in This Item:

File Description SizeFormatVisibility
PhD_Thesis_PellegriniFP_completa.pdftesto completo tesi1,41 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License
Creative Commons


Items in InsubriaSPACE are protected by copyright, with all rights reserved, unless otherwise indicated.


Share this record
Del.icio.us

Citeulike

Connotea

Facebook

Stumble it!

reddit


 

  ICT Support, development & maintenance are provided by the AePIC team @ CILEA. Powered on DSpace Software.  Feedback